Mouse SFRP1 (Secreted Frizzled Related Protein 1) Sandwich ELISA Kit (STJE0012121)
SPECIFICATIONS
General Information
| Short Description | This SFRP1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse serum, plasma, tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Mouse |
| Sensitivity | 13.3pg/mL |
| Detection Limit | 31.2-2000pg/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | Sfrp1 |
| Gene ID | 20377 |
| Uniprot ID | SFRP1_MOUSE |
| Sample Type | serum, plasma, tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | Highly expressed in kidney and embryonic heart. Also highly expressed in the eye, where it is principally localized to the ciliary body and the lens epithelium. Weaker expression in heart, lung and brain. In the brain, is expressed exclusively in the choroid plexus. |
| Post Translational Modifications | |
| Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels. Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi. Inhibits WNT1/WNT4-mediated TCF-dependent transcription. |
| Protein Name | Secreted Frizzled-Related Protein 1Sfrp-1 |
| Database Links | |
| Cellular Localisation | SecretedCell Membrane Or Extracellular Matrix-AssociatedReleased By Heparin-Binding |
| Alternative ELISA Names | Secreted Frizzled-Related Protein 1 ELISA kitSfrp-1 ELISA kitSfrp1 ELISA kit |
| output |
Information sourced from Uniprot.org