Mouse SDHA (Succinate Dehydrogenase Complex Subunit A) Sandwich ELISA Kit Ready-To-Use Kit (STJE0018449)
SPECIFICATIONS
General Information
| Short Description | This SDHA Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Mouse |
| Sensitivity | 0.117ng/mL |
| Detection Limit | 0.312-20ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | Sdha |
| Gene ID | 66945 |
| Uniprot ID | SDHA_MOUSE |
| Immunogen Region | Ready-To-Use |
| Sample Type | tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | |
| Post Translational Modifications | Acetylation of Lys-498 and Lys-538 is observed in liver mitochondria from fasted mice but not from fed mice. Deacetylated by SIRT3. Phosphorylation at Tyr-215 is important for efficient electron transfer in complex II and the prevention of ROS generation. |
| Function | Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate. Can act as a tumor suppressor. |
| Protein Name | Succinate Dehydrogenase Ubiquinone Flavoprotein Subunit - MitochondrialFlavoprotein Subunit Of Complex IiFpMalate Dehydrogenase Quinone Flavoprotein Subunit |
| Database Links | Reactome: R-MMU-71403Reactome: -MMU-9854311 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinMatrix Side |
| Alternative ELISA Names | Succinate Dehydrogenase Ubiquinone Flavoprotein Subunit - Mitochondrial ELISA kitFlavoprotein Subunit Of Complex Ii ELISA kitFp ELISA kitMalate Dehydrogenase Quinone Flavoprotein Subunit ELISA kitSdha ELISA kit |
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Information sourced from Uniprot.org