| Host: |
Goat/Rabbit |
| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
This sCD14 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Conjugation: |
Unconjugated/Biotin |
| Formulation: |
Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5. |
| Purification: |
Capture Purification: Antigen Affinity.Detection Purification: Protein A or G. |
| Concentration: |
0.5 mg/mL |
| Storage Instruction: |
Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Determination Method: |
Colormetric |
| Gene Symbol: |
Cd14 |
| Gene ID: |
12475 |
| Uniprot ID: |
CD14_MOUSE |
| Immunogen: |
Capture immunogen: Recombinant Mouse sCD14 protien.Detection Immunogen: Recombinant Mouse sCD14 protien. |
| Sample Type: |
Serum, plasma and other biological fluids |
| Function | Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Acts as an accessory receptor for M.tuberculosis lipoproteins LprA, LprG and LpqH, in conjunction with coreceptors TLR2 and TLR1. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-). |
| Protein Name | Monocyte Differentiation Antigen Cd14Myeloid Cell-Specific Leucine-Rich GlycoproteinCd Antigen Cd14 |
| Database Links | Reactome: R-MMU-140534Reactome: -MMU-166016Reactome: -MMU-166020Reactome: -MMU-166166Reactome: -MMU-2562578Reactome: -MMU-5686938Reactome: -MMU-6798695Reactome: -MMU-936964Reactome: -MMU-937041Reactome: -MMU-937072Reactome: -MMU-975163Reactome: -MMU-9824878 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecretedMembrane RaftGolgi ApparatusSolubleSecreted Forms Seem To ExistThey May Arise By Cleavage Of The Gpi Anchor |
| Alternative Antibody Pair Names | Monocyte Differentiation Antigen Cd14 antibody pairMyeloid Cell-Specific Leucine-Rich Glycoprotein antibody pairCd Antigen Cd14 antibody pairCd14 antibody pair |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
