Mouse S100A4 protein (Recombinant) (His-Tag) (STJP017215)
SPECIFICATIONS
HostE.coli
ImmunogenMouse
General Information
| Short Description | Recombinant-Mouse S100A4-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 2mM DTT, 0.1M NaCl. |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
Target Information
| Gene Symbol | S100a4 |
| Gene ID | 20198 |
| Uniprot ID | S10A4_MOUSE |
| Accession Number | NP_035441 |
| Immunogen | Mouse |
| Immunogen Region | 1-101aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Specifically expressed in different metastatic cells. |
| Function | Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9. Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis. Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels. Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes. In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors. |
| Protein Name | Protein S100-A4MetastasinMetastatic Cell ProteinPel98Placental Calcium-Binding ProteinProtein 18a2Protein Mts1S100 Calcium-Binding Protein A4 |
| Database Links | |
| Cellular Localisation | SecretedNucleusCytoplasm |
| Alternative Protein Names | Protein S100-A4 proteinMetastasin proteinMetastatic Cell Protein proteinPel98 proteinPlacental Calcium-Binding Protein proteinProtein 18a2 proteinProtein Mts1 proteinS100 Calcium-Binding Protein A4 proteinS100a4 proteinCapl proteinMts1 protein |
Information sourced from Uniprot.org