Mouse PPARG protein (Recombinant) (N-His) (STJP011230)
SPECIFICATIONS
HostE.coli
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Mouse PPARG-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | Pparg |
| Gene ID | 19016 |
| Uniprot ID | PPARG_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Met31-Tyr505 |
Additional Info
| Post Translational Modifications | O-GlcNAcylation at Thr-84 reduces transcriptional activity in adipocytes. Phosphorylated in basal conditions and dephosphorylated when treated with the ligand. May be dephosphorylated by PPP5C. The phosphorylated Ser-112 form is recognized by PER2 and repressed, dephosphorylation at Ser-112 induces adipogenic activity. Ser-112 phosphorylation levels are reduced by 65% in brown adipose tissue compared to white adipose tissue. Ubiquitinated by E3 ubiquitin-protein ligase complex containing FBXO9.leading to proteasomal degradation. Ubiquitinated by E3 ubiquitin-protein ligase complex containing FBXO9.leading to proteasomal degradation. Ubiquitinated at Lys-252 by TRIM55 leading to proteasomal degradation. Ubiquitinated by E3 ubiquitin-protein ligase STUB1/CHIP.leading to proteasomal degradation. |
| Function | Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels. |
| Protein Name | Peroxisome Proliferator-Activated Receptor GammaPpar-GammaNuclear Receptor Subfamily 1 Group C Member 3 |
| Database Links | Reactome: R-MMU-381340Reactome: -MMU-383280Reactome: -MMU-9841922 |
| Cellular Localisation | NucleusCytoplasmRedistributed From The Nucleus To The Cytosol Through A Map2k1/Mek1-Dependent MannerNoct Enhances Its Nuclear Translocation |
| Alternative Protein Names | Peroxisome Proliferator-Activated Receptor Gamma proteinPpar-Gamma proteinNuclear Receptor Subfamily 1 Group C Member 3 proteinPparg proteinNr1c3 protein |
Information sourced from Uniprot.org