This PICK1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates, cell lysates or other biological fluids..
Applications
ELISA
Reactivity
Mouse
Sensitivity
0.053ng/mL
Detection Limit
0.156-10ng/mL
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Storage Instruction
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
tissue homogenates, cell lysates or other biological fluids.
Additional Info
Tissue Specificity
Expressed in all tissues examined, with highest levels in brain and testes and lowest levels in lung.
Post Translational Modifications
Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors. Phosphorylated on tyrosine residues by EPHB2 and on serine or threonine residues by PKC. Palmitoylation on Cys-414 is essential for long-term synaptic depression (LTD).
Function
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex.the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
Protein Name
Prkca-Binding ProteinProtein Interacting With C Kinase 1Protein Kinase C-Alpha-Binding Protein
Database Links
Cellular Localisation
CytoplasmPerinuclear RegionMembranePeripheral Membrane ProteinLipid-AnchorPostsynaptic DensitySynapseSynaptosomeCytoskeletonAlso Membrane-AssociatedPresent At Excitatory Synapses
Alternative ELISA Names
Prkca-Binding Protein ELISA kitProtein Interacting With C Kinase 1 ELISA kitProtein Kinase C-Alpha-Binding Protein ELISA kitPick1 ELISA kitPrkcabp ELISA kit
