|  Tissue Specificity  |    |  
  |  Post Translational Modifications  |    |  
  |  Function  |   Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells.  |  
  |  Protein Name  |   2' -5'-Phosphodiesterase 122'-Pde2-PdeMitochondrial Deadenylase  |  
  |  Database Links  |   Reactome: R-MMU-8983711  |  
  |  Cellular Localisation  |   Mitochondrion Matrix  |  
  |  Alternative ELISA Names  |   2' -5'-Phosphodiesterase 12 ELISA kit2'-Pde ELISA kit2-Pde ELISA kitMitochondrial Deadenylase ELISA kitPde12 ELISA kit  |  
  |  output  |    |  
 
Information sourced from Uniprot.org