Mouse p75 NGF Receptor (p75 NGF Receptor) Antibody Pair (STJAP00808)
General Information
| Short Description | This p75 NGF Receptor antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R15-8P-7/R49-1F-9 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | Ngfr |
| Gene ID | 18053 |
| Uniprot ID | TNR16_MOUSE |
| Immunogen | Recombinant protein |
Additional Info
| Tissue Specificity | Detected in Schwann cells. Detected in embryonic brain, in hippocampus neurons (at protein level). Detected in brain and spinal cord. |
| Post Translational Modifications | N-glycosylated. O-glycosylated. Phosphorylated on serine residues. |
| Function | Low affinity neurotrophin receptor which can bind to mature NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF (proNGF), BDNF (proBDNF) and NTF3 (proNT3) with high affinity, and has much lower affinity for mature NGF and BDNF. Plays an important role in differentiation and survival of specific neuronal populations during development. Can mediate cell survival as well as cell death of neural cells. The heterodimeric receptor formed with SORCS2 plays a role in proBDNF-dependent synaptic plasticity, in hippocampal long term depression (LTD) and long term potentiation (LTP). Plays a role in the inactivation of RHOA. Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver. (Microbial infection) Cell surface receptor for rabies virus glycoprotein Gs. Isoform 2: Does not bind NGF, BDNF, NTF3, and NTF4. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 16Low Affinity Neurotrophin Receptor P75ntrLow-Affinity Nerve Growth Factor ReceptorNgf ReceptorLow-Affinity Nerve Growth Factor Receptor P75ngfrLow-Affinity Nerve Growth Factor Receptor P75ngrCd Antigen Cd271 |
| Database Links | Reactome: R-MMU-193634Reactome: -MMU-193692Reactome: -MMU-205017Reactome: -MMU-205025Reactome: -MMU-205043Reactome: -MMU-209543Reactome: -MMU-209560Reactome: -MMU-209563 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCytoplasmPerikaryonCell ProjectionGrowth ConeDendritic Spine |
| Alternative Antibody Pair Names | Tumor Necrosis Factor Receptor Superfamily Member 16 antibody pairLow Affinity Neurotrophin Receptor P75ntr antibody pairLow-Affinity Nerve Growth Factor Receptor antibody pairNgf Receptor antibody pairLow-Affinity Nerve Growth Factor Receptor P75ngfr antibody pairLow-Affinity Nerve Growth Factor Receptor P75ngr antibody pairCd Antigen Cd271 antibody pairNgfr antibody pairTnfrsf16 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Mouse p75 NGF Receptor (p75 NGF Receptor) Antibody Pair (STJAP00808)
This antibody pair detects mouse p75 NGF Receptor (UniProt Q9Z0W1) and is validated for reactivity in mouse samples only.
Both antibodies are supplied as unconjugated, affinity-purified rabbit monoclonal IgGs (clone IDs R15-8P-7 and R49-1F-9) at a concentration of 1 mg/mL, formulated in 0.01M PBS at pH 7.2.
This antibody pair is validated for use in ELISA. No other assay formats are listed in the product specifications.
Working dilutions are not pre-defined in the product specifications and must be determined by the end user through titration optimization within their specific experimental setup.
Both antibodies should be stored at 4°C for short-term use. For long-term storage, aliquot and store at -20°C, and avoid repeated freeze/thaw cycles to maintain activity.
Both monoclonal antibodies in this pair were raised against a recombinant protein immunogen corresponding to mouse p75 NGF Receptor. No further detail on the specific immunogen region is provided in the product specifications.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.