Mouse OX (Orexin) Sandwich ELISA Kit (STJE0011223)
SPECIFICATIONS
General Information
| Short Description | This OX Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Mouse |
| Sensitivity | 2.27pg/mL |
| Detection Limit | 7.81-500pg/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | Hcrt |
| Gene ID | 15171 |
| Uniprot ID | OREX_MOUSE |
| Sample Type | serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Additional Info
| Tissue Specificity | Restricted to neuronal cell bodies of the dorsal and lateral hypothalamus. |
| Post Translational Modifications | Specific enzymatic cleavages at paired basic residues yield the different active peptides. |
| Function | Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A: Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner. Orexin-B: Binds to orexin receptor HCRTR2/OX2R only. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner. |
| Protein Name | Hypocretin Neuropeptide PrecursorHypocretinHcrtOrexin PrecursorPrepro-OrexinPreprohypocretin Cleaved Into - Orexin-AHypocretin-1Hcrt1 - Orexin-BHypocretin-2Hcrt2 |
| Database Links | Reactome: R-MMU-389397Reactome: -MMU-416476 |
| Cellular Localisation | Rough Endoplasmic ReticulumCytoplasmic VesicleSynapseAssociated With Perikaryal Rough Endoplasmic Reticulum As Well As Cytoplasmic Large Granular Vesicles At Synapses |
| Alternative ELISA Names | Hypocretin Neuropeptide Precursor ELISA kitHypocretin ELISA kitHcrt ELISA kitOrexin Precursor ELISA kitPrepro-Orexin ELISA kitPreprohypocretin Cleaved Into - Orexin-A ELISA kitHypocretin-1 ELISA kitHcrt1 - Orexin-B ELISA kitHypocretin-2 ELISA kitHcrt2 ELISA kitHcrt ELISA kitOx ELISA kitPpox ELISA kit |
| output |
Information sourced from Uniprot.org