| Host: |
HEK293 |
| Note: |
STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse Neuroligin-1-protein was developed from hek293. For use in research applications. |
| Conjugation: |
Unconjugated |
| Formulation: |
Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose. |
| Storage Instruction: |
Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin: |
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
| Gene Symbol: |
Nlgn1 |
| Gene ID: |
192167 |
| Uniprot ID: |
NLGN1_MOUSE |
| Immunogen Region: |
GLN46-SER677 |
| Immunogen: |
Optimized DNA sequence encoding I extracellular domain of Mouse Neuroligin-1 (NLGN1 ) (GLN46-SER677 ) including a C-terminal His tag was expressed in HEK293 cells. NA |
| Tissue Specificity | Brain and arteries (at protein level). Expressed in olfactory bulb. Detected in brain. |
| Function | Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep. The protein is involved in nervous system development. |
| Protein Name | Neuroligin-1 |
| Database Links | Reactome: R-MMU-6794361 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPostsynaptic DensitySynaptic CleftSynaptic Cell MembraneEnriched In Synaptic Plasma Membranes And Clustered In Synaptic Clefts And Postsynaptic DensitiesColocalized With Dlg4/Psd-95 And Grin1/Nmdar1 |
| Alternative Protein Names | Neuroligin-1 proteinNlgn1 proteinKiaa1070 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
