Mouse MMP3 (MMP3) Antibody Pair (STJAP00789)
General Information
| Short Description | This MMP3 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R32-7C-1/R62-3X-6 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | Mmp3 |
| Gene ID | 17392 |
| Uniprot ID | MMP3_MOUSE |
| Immunogen | Recombinant protein |
Additional Info
| Function | Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V.collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9. Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway. Also acts intracellularly. For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage. In addition, plays a role in immune response and possesses antiviral activity against various viruses. Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities. |
| Protein Name | Stromelysin-1Sl-1Ems-2Matrix Metalloproteinase-3Mmp-3Transin-1 |
| Database Links | Reactome: R-MMU-1442490Reactome: -MMU-1474228Reactome: -MMU-1592389Reactome: -MMU-2022090Reactome: -MMU-2179392Reactome: -MMU-9009391 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Pair Names | Stromelysin-1 antibody pairSl-1 antibody pairEms-2 antibody pairMatrix Metalloproteinase-3 antibody pairMmp-3 antibody pairTransin-1 antibody pairMmp3 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Mouse MMP3 (MMP3) Antibody Pair (STJAP00789)
This antibody pair is designed to detect mouse MMP3 (Matrix Metalloproteinase 3), corresponding to UniProt entry P28862. Reactivity has been confirmed for mouse samples only.
This antibody pair is validated for use in ELISA. It is intended for sandwich ELISA configurations using one antibody as capture and the other as detection.
Both antibodies are rabbit monoclonal IgGs, supplied unconjugated at 1 mg/mL in 0.01M PBS, pH 7.2. Clone IDs are R32-7C-1 and R62-3X-6, and both are affinity purified.
Working dilutions are to be determined by the end user. Titration experiments are recommended to establish optimal capture and detection antibody concentrations for each specific experimental setup.
Both antibodies should be stored at 4°C for short-term use. For long-term storage, aliquot and store at -20°C, and avoid repeated freeze/thaw cycles to maintain activity.
Both antibodies in this pair were raised in rabbit against a recombinant protein immunogen corresponding to mouse MMP3. No additional immunogen region details are specified for this product.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.