Mouse MECOM protein (Recombinant) (N-His) (STJP011132)
SPECIFICATIONS
HostE.coli
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Mouse MECOM-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | Mecom |
| Gene ID | 14013 |
| Uniprot ID | MECOM_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Asp74-Ser193 |
Additional Info
| Function | Isoform 1: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. Isoform 3: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. |
| Protein Name | Histone-Lysine N-Methyltransferase MecomEcotropic Virus Integration Site 1 ProteinEvi-1Mds1 And Evi1 Complex Locus ProteinMyelodysplasia Syndrome 1 Protein Homolog |
| Database Links | |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasm |
| Alternative Protein Names | Histone-Lysine N-Methyltransferase Mecom proteinEcotropic Virus Integration Site 1 Protein proteinEvi-1 proteinMds1 And Evi1 Complex Locus Protein proteinMyelodysplasia Syndrome 1 Protein Homolog proteinMecom proteinEvi1 proteinMds1 proteinPrdm3 protein |
Information sourced from Uniprot.org