Mouse LTBP1 (Latent Transforming Growth Factor Beta Binding Protein 1) Sandwich ELISA Kit Ready-To-Use Kit (STJE0016826)
SPECIFICATIONS
General Information
| Short Description | This LTBP1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse serum, plasma, tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Mouse |
| Sensitivity | 0.053ng/mL |
| Detection Limit | 0.156-10ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | Ltbp1 |
| Gene ID | 268977 |
| Uniprot ID | LTBP1_MOUSE |
| Immunogen Region | Ready-To-Use |
| Sample Type | serum, plasma, tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | |
| Post Translational Modifications | Contains hydroxylated asparagine residues. Two intrachain disulfide bonds from the TB3 domain are rearranged upon TGFB1 binding, and form interchain bonds with TGFB1 propeptide, anchoring it to the extracellular matrix. O-glycosylated on serine residues by POGLUT2 and POGLUT3. |
| Function | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta. |
| Protein Name | Latent-Transforming Growth Factor Beta-Binding Protein 1Ltbp-1Transforming Growth Factor Beta-1-Binding Protein 1Tgf-Beta1-Bp-1 |
| Database Links | Reactome: R-MMU-2129379Reactome: -MMU-2173789Reactome: -MMU-381426Reactome: -MMU-8957275 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative ELISA Names | Latent-Transforming Growth Factor Beta-Binding Protein 1 ELISA kitLtbp-1 ELISA kitTransforming Growth Factor Beta-1-Binding Protein 1 ELISA kitTgf-Beta1-Bp-1 ELISA kitLtbp1 ELISA kit |
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Information sourced from Uniprot.org