Mouse L-Selectin (CD62L) protein (Recombinant) (STJP000462)
SPECIFICATIONS
HostHEK293
ConjugationUnconjugated
ImmunogenOptimized DNA sequence encoding extracellular domain of Mouse L-Selectin including a C-terminal IgG1 Fc tag was expressed in HEK293 cells. NA
General Information
| Short Description | Recombinant-Mouse L-Selectin (CD62L)-protein was developed from hek293. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose. |
| Storage Instruction | Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
| Immunoreactivity | The activity was tested by the ability of immobilized recombinant Mouse L-Selectin to bind Human U937 lymphoma cells NA |
Target Information
| Gene Symbol | Sell |
| Gene ID | 20343 |
| Uniprot ID | LYAM1_MOUSE |
| Immunogen | Optimized DNA sequence encoding extracellular domain of Mouse L-Selectin including a C-terminal IgG1 Fc tag was expressed in HEK293 cells. NA |
| Immunogen Region | ECD |
Additional Info
| Tissue Specificity | Predominantly expressed in lymphoid tissue. |
| Post Translational Modifications | N-glycosylated. |
| Function | Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. |
| Protein Name | L-SelectinCd62 Antigen-Like Family Member LLeukocyte Adhesion Molecule 1Lam-1Leukocyte-Endothelial Cell Adhesion Molecule 1Lecam1Lymph Node Homing ReceptorLymphocyte Antigen 22Ly-22Lymphocyte Surface Mel-14 AntigenCd Antigen Cd62l |
| Database Links | Reactome: R-MMU-198933Reactome: -MMU-202733Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | L-Selectin proteinCd62 Antigen-Like Family Member L proteinLeukocyte Adhesion Molecule 1 proteinLam-1 proteinLeukocyte-Endothelial Cell Adhesion Molecule 1 proteinLecam1 proteinLymph Node Homing Receptor proteinLymphocyte Antigen 22 proteinLy-22 proteinLymphocyte Surface Mel-14 Antigen proteinCd Antigen Cd62l proteinSell proteinLnhr proteinLy-22 proteinLy22 protein |
Information sourced from Uniprot.org