Mouse KRT18 (Keratin 18) Sandwich ELISA Kit (STJE0010224)
SPECIFICATIONS
General Information
| Short Description | This KRT18 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Mouse |
| Sensitivity | 25pg/mL |
| Detection Limit | 78.1-5000pg/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | Krt18 |
| Gene ID | 16668 |
| Uniprot ID | K1C18_MOUSE |
| Sample Type | serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Additional Info
| Tissue Specificity | Expressed in endoderm, intestinal epithelial cells and in most extraembryonic tissues. |
| Post Translational Modifications | Phosphorylation increases by IL-6. Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-231 by either caspase-3, caspas-6 or caspase-7. O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation. |
| Function | When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. |
| Protein Name | Keratin - Type I Cytoskeletal 18Cytokeratin Endo BKeratin DCytokeratin-18Ck-18Keratin-18K18 |
| Database Links | Reactome: R-MMU-6805567Reactome: -MMU-6809371 |
| Cellular Localisation | Nucleus MatrixCytoplasmPerinuclear RegionNucleusNucleolus |
| Alternative ELISA Names | Keratin - Type I Cytoskeletal 18 ELISA kitCytokeratin Endo B ELISA kitKeratin D ELISA kitCytokeratin-18 ELISA kitCk-18 ELISA kitKeratin-18 ELISA kitK18 ELISA kitKrt18 ELISA kitKerd ELISA kitKrt1-18 ELISA kit |
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Information sourced from Uniprot.org