| Tissue Specificity | Highest level in the heart and 15- and 17-day embryos. Low level in other tissues. Colocalized with gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus. |
| Post Translational Modifications | |
| Function | Receptor for metastin (kisspeptin-52 or kp-52), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. |
| Protein Name | Kiss-1 ReceptorKiss-1rG-Protein Coupled Receptor 54G-Protein Coupled Receptor Ot7t175Mot7t175Kisspeptins ReceptorMetastin Receptor |
| Database Links | Reactome: R-MMU-375276Reactome: -MMU-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative ELISA Names | Kiss-1 Receptor ELISA kitKiss-1r ELISA kitG-Protein Coupled Receptor 54 ELISA kitG-Protein Coupled Receptor Ot7t175 ELISA kitMot7t175 ELISA kitKisspeptins Receptor ELISA kitMetastin Receptor ELISA kitKiss1r ELISA kitGpr54 ELISA kit |
| output | |
Information sourced from Uniprot.org
