Mouse IP-10/CXCL10 (C-X-C Motif Chemokine 10) Antibody Pair (STJAP00522)
General Information
| Short Description | This IP-10/CXCL10 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Goat/Goat |
| Reactivity | Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Antigen Affinity.Detection Purification: Antigen Affinity. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
| Determination Method | Colormetric |
Target Information
| Gene Symbol | Cxcl10 |
| Gene ID | 15945 |
| Uniprot ID | CXL10_MOUSE |
| Immunogen | Capture immunogen: Recombinant Mouse IP-10/CXCL10 protien.Detection Immunogen: Recombinant Mouse IP-10/CXCL10 protien. |
| Sample Type | Serum, plasma and other biological fluids |
Additional Info
| Function | Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization. |
| Protein Name | C-X-C Motif Chemokine 1010 Kda Interferon Gamma-Induced ProteinGamma-Ip10Ip-10C7Interferon-Gamma Induced Protein Crg-2Small-Inducible Cytokine B10 |
| Database Links | Reactome: R-MMU-380108Reactome: -MMU-418594 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | C-X-C Motif Chemokine 10 antibody pair10 Kda Interferon Gamma-Induced Protein antibody pairGamma-Ip10 antibody pairIp-10 antibody pairC7 antibody pairInterferon-Gamma Induced Protein Crg-2 antibody pairSmall-Inducible Cytokine B10 antibody pairCxcl10 antibody pairCrg2 antibody pairIfi10 antibody pairInp10 antibody pairScyb10 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Mouse IP-10/CXCL10 (C-X-C Motif Chemokine 10) Antibody Pair (STJAP00522)
This antibody pair detects mouse IP-10/CXCL10 (C-X-C Motif Chemokine 10), with reactivity confirmed for mouse. It corresponds to UniProt entry P17515.
Both antibodies are goat-derived and purified by antigen affinity. The capture antibody is unconjugated and supplied at 0.5 mg/mL in PBS with 0.04% Proclin 300 and 50% glycerol at pH 7.5, while the detection antibody is biotinylated and supplied at 0.5 mg/mL in PBS with 0.04% Proclin 300, 1% protective protein, and 50% glycerol at pH 7.5.
This antibody pair is validated for use in ELISA. It is intended for the detection of mouse IP-10/CXCL10 in serum, plasma, and other biological fluids.
Both the capture and detection antibodies were raised against recombinant mouse IP-10/CXCL10 protein and subsequently purified by antigen affinity chromatography.
Both components should be stored at -20°C for long-term storage. Repeated freeze-thaw cycles should be avoided to maintain reagent integrity.
This antibody pair is suitable for use with mouse serum, plasma, and other biological fluids when configured in an ELISA format. This product is for research use only and is not intended for diagnostic or therapeutic applications.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.