| Post Translational Modifications | Phosphorylated by GSK3B at Ser-442.leading to proteasomal degradation. Ubiquitinated at Lys-326 in a FBXL19-mediated manner.leading to proteasomal degradation. Ubiquitination by TRAF6 via 'Lys-27'-linked polyubiquitination and deubiquitination by USP38 serves as a critical regulatory mechanism for fine-tuning IL1RL1-mediated inflammatory response. |
| Function | Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. Isoform B: Inhibits IL-33 signaling. |
| Protein Name | Interleukin-1 Receptor-Like 1Interleukin-33 Receptor Alpha ChainLymphocyte Antigen 84Protein St2Protein T1 |
| Database Links | Reactome: R-MMU-1257604Reactome: -MMU-6811558Reactome: -MMU-9014843 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform B: Secreted |
| Alternative Protein Names | Interleukin-1 Receptor-Like 1 proteinInterleukin-33 Receptor Alpha Chain proteinLymphocyte Antigen 84 proteinProtein St2 proteinProtein T1 proteinIl1rl1 proteinLy84 proteinSt2 proteinSte2 protein |
Information sourced from Uniprot.org
