Mouse IL-3 (IL-3) Antibody Pair (STJAP00951)
SPECIFICATIONS
HostGoat/Rat
ConjugationUnconjugated/Biotin
General Information
| Short Description | This IL-3 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Goat/Rat |
| Reactivity | Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL/0.5-4ug/mL |
| Dilution Range | 1:1000-1:10000 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
| Detection | Colorimetric method;ELISA;Sandwich |
Target Information
| Gene Symbol | Il3 |
| Gene ID | 16187 |
| Uniprot ID | IL3_MOUSE |
| Sample Type | Serum, plasma and other biological fluids |
Additional Info
| Function | Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Also stimulates mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK. |
| Protein Name | Interleukin-3Il-3Hematopoietic Growth FactorMast Cell Growth FactorMcgfMultipotential Colony-Stimulating FactorP-Cell-Stimulating Factor |
| Database Links | Reactome: R-MMU-512988Reactome: -MMU-5673001Reactome: -MMU-912526 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Interleukin-3 antibody pairIl-3 antibody pairHematopoietic Growth Factor antibody pairMast Cell Growth Factor antibody pairMcgf antibody pairMultipotential Colony-Stimulating Factor antibody pairP-Cell-Stimulating Factor antibody pairIl3 antibody pairCsfmu antibody pairIl-3 antibody pair |
Information sourced from Uniprot.org