Mouse IL-20 protein (Recombinant) (C-His) (STJP003035)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Mouse IL-20 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu25-Leu176) of Mouse IL-20 (Accession #Q9JKV9) fused with a His tag at the N-terminus.
General Information
| Short Description | Recombinant-Mouse IL-20-C-His protein was developed in hek293 cells using the region Leu25-Leu176. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of 20mM PB, 500mM NaCl, pH 8.0. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.01 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | Il20 |
| Gene ID | 58181 |
| Uniprot ID | IL20_MOUSE |
| Immunogen | Recombinant Mouse IL-20 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu25-Leu176) of Mouse IL-20 (Accession #Q9JKV9) fused with a His tag at the N-terminus. |
| Immunogen Region | Leu25-Leu176 |
| Immunogen Sequence | QDSTSDLIPAPPLSKVPLQQ NFQDNQFQGKWYVVGLAGNA ILREDKDPQKMYATIYELKE DKSYNVTSVLFRKKKCDYWI RTFVPGCQPGEFTLGNIKSY PGLTSYLVRVVSTNYNQHAM VFFKKVSQNREYFKITLYGR TKELTSELKENFIRFSKSLG LPENHIVFPVPIDQCIDG |
Additional Info
| Function | Pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes that plays crucial roles in immune responses, regulation of inflammatory responses, hemopoiesis, as well as epidermal cell and keratinocyte differentiation. Enhances tissue remodeling and wound-healing activities and restores the homeostasis of epithelial layers during infection and inflammatory responses to maintain tissue integrity. Affects multiple actin-mediated functions in activated neutrophils leading to inhibition of phagocytosis, granule exocytosis, and migration. Exert its effects via the type I IL-20 receptor complex consisting of IL20RA and IL20RB. Alternatively, can mediate its activity through a second receptor complex called type II IL-20 receptor complex composed of IL22RA1 and IL20RB. Acts as an arteriogenic and vascular remodeling factory by activating a range of signaling processes including phosphorylations of JAK2 and STAT5 as well as activation of the serine and threonine kinases AKT and ERK1/2. Alternatively, can activate STAT3 phosphorylation and transcriptional activity in a JAK2, ERK1/2 and p38 MAPK-dependent manner in keratinocytes. |
| Protein Name | Interleukin-20Il-20Cytokine Zcyto10 |
| Database Links | Reactome: R-MMU-8854691 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interleukin-20 proteinIl-20 proteinCytokine Zcyto10 proteinIl20 proteinZcyto10 protein |
Information sourced from Uniprot.org