Mouse IGF-2 (Insulin-Like Growth Factor 2) Antibody Pair (STJAP00314)
General Information
| Short Description | This IGF-2 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Goat/Rat |
| Reactivity | Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal/Monoclonal |
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Antigen Affinity.Detection Purification: Protein A or G. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Igf2 |
| Gene ID | 16002 |
| Uniprot ID | IGF2_MOUSE |
| Immunogen | Capture immunogen: Recombinant Mouse IGF-2 protein.Detection Immunogen: Recombinant Mouse IGF-2 protein. |
Additional Info
| Post Translational Modifications | Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2. |
| Function | The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development (Probable). IGF2 is influenced by placental lactogen (Probable). Also involved in tissue differentiation (Probable). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate. Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. |
| Protein Name | Insulin-Like Growth Factor 2Insulin-Like Growth Factor IiIgf-IiMultiplication-Stimulating Polypeptide Cleaved Into - Preptin |
| Database Links | Reactome: R-MMU-114608Reactome: -MMU-2404192Reactome: -MMU-2428928Reactome: -MMU-2428933Reactome: -MMU-381426 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Insulin-Like Growth Factor 2 antibody pairInsulin-Like Growth Factor Ii antibody pairIgf-Ii antibody pairMultiplication-Stimulating Polypeptide Cleaved Into - Preptin antibody pairIgf2 antibody pairIgf-2 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Mouse IGF-2 (Insulin-Like Growth Factor 2) Antibody Pair (STJAP00314)
This antibody pair is designed to detect mouse IGF-2 (Insulin-Like Growth Factor 2), with confirmed reactivity against the mouse protein (UniProt P09535). It is not validated for use with human or rat IGF-2 samples based on the information provided.
The capture antibody is an unconjugated goat polyclonal antibody purified by antigen affinity, while the detection antibody is a biotin-conjugated rat monoclonal antibody purified by Protein A or G. Both components are supplied at 0.5 mg/mL in PBS containing 0.04% Proclin 300 and 50% glycerol, pH 7.4.
This pair has been validated for use in ELISA. No other assay formats, such as lateral flow or multiplex, are listed in the product specifications.
Both the capture and detection antibodies were raised against recombinant mouse IGF-2 protein. No specific immunogen region or sequence information is provided in the current product details.
Both components should be stored at -20°C for long-term storage. Freeze-thaw cycles should be avoided to maintain reagent integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.