| Host: |
HEK293 |
| Note: |
STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse IFNB1-protein was developed from hek293. For use in research applications. |
| Conjugation: |
Unconjugated |
| Formulation: |
Lyophilised from 0.2 µm filtered PBS solution pH7.4. |
| Dilution Range: |
Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers. |
| Storage Instruction: |
The lyophilized protein is stable for at least 1 year from date of receipt at-20°C. NA |
| Endotoxin: |
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
| Immunoreactivity: |
The activity was determined by a viral resistance assay of Human WISH cells, and was found to be in the range of 1x10^8 IU/mg. NA |
| Gene Symbol: |
Ifnb1 |
| Gene ID: |
15977 |
| Uniprot ID: |
IFNB_MOUSE |
| Immunogen Region: |
Mature chain |
| Immunogen: |
DNA sequence encoding the mature chain of Mouse IFNB1 was expressed in HEK293 Cells. NA |
| Immunogen Sequence: |
ALSINYKQLQ LQERTNIRKC QELLEQLNGK INLTYRADFK IPMEMTEKMQ KSYTAFAIQE MLQNVFLVFR NNFSSTGWNE TIVVRLLDEL HQQTVFLKTV LEEKQEERLT WEMSSTALHL KSYYWRVQRY LKLMKYNSYA WMVVRAEIFR NFLIIRRLTR NA |
| Post Translational Modifications | This beta interferon does not have a disulfide bond. |
| Function | Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways. Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor. Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth. |
| Protein Name | Interferon BetaIfn-Beta |
| Database Links | Reactome: R-MMU-909733Reactome: -MMU-912694 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interferon Beta proteinIfn-Beta proteinIfnb1 proteinIfb proteinIfnb protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
