Mouse HTT (Huntingtin) Sandwich ELISA Kit Ready-To-Use Kit (STJE0015990)
SPECIFICATIONS
General Information
| Short Description | This HTT Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Mouse |
| Sensitivity | 0.055ng/mL |
| Detection Limit | 0.156-10ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | HttUniprot ID=HD_MOUSE" |
| Immunogen Region | Ready-To-Use |
| Sample Type | serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Additional Info
| Tissue Specificity | The highest level is seen throughout the brain, but it is also found in the stomach, heart, testis, adipose tissue, muscle, spleen, liver, and kidney. |
| Post Translational Modifications | Phosphorylation at Ser-1159 and Ser-1179 by CDK5 in response to DNA damage in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Huntingtin: Cleaved by caspases downstream of the polyglutamine stretch. Huntingtin, myristoylated N-terminal fragment: Myristoylated at Gly-530, following proteolytic cleavage at Asp-529. |
| Function | Huntingtin: May play a role in microtubule-mediated transport or vesicle function. Huntingtin, myristoylated N-terminal fragment: Promotes the formation of autophagic vesicles. |
| Protein Name | HuntingtinHuntington Disease Protein HomologHd Protein Homolog Cleaved Into - Huntingtin - Myristoylated N-Terminal Fragment |
| Database Links | |
| Cellular Localisation | Huntingtin: CytoplasmNucleusShuttles Between Cytoplasm And Nucleus In A Ran Gtpase-Independent MannerHuntingtinMyristoylated N-Terminal Fragment: Cytoplasmic VesicleAutophagosome |
| Alternative ELISA Names | Huntingtin ELISA kitHuntington Disease Protein Homolog ELISA kitHd Protein Homolog Cleaved Into - Huntingtin - Myristoylated N-Terminal Fragment ELISA kitHtt ELISA kitHd ELISA kitHdh ELISA kit |
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Information sourced from Uniprot.org