Mouse HDAC9 protein (Recombinant) (N-His) (STJP011161)
SPECIFICATIONS
HostE.coli
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Mouse HDAC9-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | Hdac9 |
| Gene ID | 79221 |
| Uniprot ID | HDAC9_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Val37-Pro161 |
Additional Info
| Post Translational Modifications | Sumoylated. Phosphorylated on Ser-220 and Ser-450.which promotes 14-3-3-binding, impairs interaction with MEF2, and antagonizes antimyogenic activity. Phosphorylated on Ser-240 by DYRK1B.which impairs nuclear accumulation. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. |
| Function | Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting HDAC1 and HDAC3. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription, inhibits skeletal myogenesis and may be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. |
| Protein Name | Histone Deacetylase 9Hd9Histone Deacetylase 7bHd7bHistone Deacetylase-Related ProteinMef2-Interacting Transcription Repressor Mitr |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Histone Deacetylase 9 proteinHd9 proteinHistone Deacetylase 7b proteinHd7b proteinHistone Deacetylase-Related Protein proteinMef2-Interacting Transcription Repressor Mitr proteinHdac9 proteinHdac7b proteinHdrp proteinMitr protein |
Information sourced from Uniprot.org