Mouse GRN (Progranulin) Antibody Pair (STJAP00323)
General Information
| Short Description | This GRN antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Protein A.Detection Purification: Protein A. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Grn |
| Gene ID | 14824 |
| Uniprot ID | GRN_MOUSE |
| Immunogen | Capture immunogen: Recombinant Mouse GRN protein.Detection Immunogen: Recombinant Mouse GRN protein. |
Additional Info
| Post Translational Modifications | N-glycosylated. Cleaved by ELANE.proteolysis is blocked by SLPI and is concentration- and time-dependent and induces CXCL8/IL-8 production.granulin-3 and granulin-4 are resistant to ELANE. Cleaved by CTSL in lysosome thus regulating the maturation and turnover of progranulin within the lysosome. |
| Function | Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes. Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases. Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity. Granulin-3: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8. Granulin-7: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity. |
| Protein Name | ProgranulinPgrnAcrograninEpithelin/Granulin PrecursorGlycoprotein Of 88 KdaGp88Glycoprotein 88Pc Cell-Derived Growth FactorPcdgfProepithelinPepi Cleaved Into - Paragranulin - Granulin-1 - Granulin-2 - Granulin-3 - Granulin-4 - Granulin-5 - Granulin-6 - Granulin-7 |
| Database Links | Reactome: R-MMU-6798695 |
| Cellular Localisation | SecretedLysosomeEndocytosed By Sort1 And Delivred To LysosomesTargeted To Lysosome By Psap Via M6pr And Lrp1In Both Biosynthetic And Endocytic PathwaysCo-Localized With Gba1 In The Intracellular Trafficking Compartments Until To Lysosome |
| Alternative Antibody Pair Names | Progranulin antibody pairPgrn antibody pairAcrogranin antibody pairEpithelin/Granulin Precursor antibody pairGlycoprotein Of 88 Kda antibody pairGp88 antibody pairGlycoprotein 88 antibody pairPc Cell-Derived Growth Factor antibody pairPcdgf antibody pairProepithelin antibody pairPepi Cleaved Into - Paragranulin - Granulin-1 - Granulin-2 - Granulin-3 - Granulin-4 - Granulin-5 - Granulin-6 - Granulin-7 antibody pairGrn antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Mouse GRN (Progranulin) Antibody Pair (STJAP00323)
This antibody pair detects mouse GRN (Progranulin), corresponding to UniProt entry P28798. Reactivity has been confirmed for mouse only.
The capture antibody is supplied unconjugated at 0.5 mg/mL, while the detection antibody is supplied at 0.5 mg/mL conjugated to biotin. Both are rabbit monoclonal antibodies purified by Protein A and formulated in PBS with 0.04% Proclin 300 and 50% glycerol at pH 7.4.
This antibody pair has been validated for use in ELISA. No other assay formats are listed for this product.
Both the capture and detection antibodies were raised against recombinant mouse GRN protein. No additional immunogen region details are provided.
Both components should be stored at -20°C for long-term storage. Freeze-thaw cycles should be avoided to maintain reagent integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.