Mouse FKBP12/FKBP1A protein (Recombinant) (His-Tag) (STJP019160)

Name: Mouse FKBP12/FKBP1A protein (Recombinant) (His-Tag) (STJP019160)
SKU: STJP019160
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenMouse

STJP019160

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Short Description	Recombinant-Mouse FKBP12/FKBP1A-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	0.5 mg/mL
Formulation	Liquid in phosphate-Buffered Saline (pH 7.4) containing 20% Glycerol, 1mM DTT
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	Fkbp1a
Gene ID	14225
Uniprot ID	FKB1A_MOUSE
Accession Number	NP_032045
Immunogen	Mouse
Immunogen Region	1-108aa
Immunogen Sequence	MGSSHHHHHH SSGLVPRGSH MGSHMGVQVE TISPGDGRTF PKRGQTCVVH YTGMLEDGKK FDSSRDRNKP FKFTLGKQEV IRGWEEGVAQ MSVGQRAKLI ISSDYAYGAT GHPGIIPPHA TLVFDVELLK LE

Function	Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Protein Name	Peptidyl-Prolyl Cis-Trans Isomerase Fkbp1a Ppiase Fkbp1a 12 Kda Fk506-Binding Protein 12 Kda Fkbp Fkbp-12 Calstabin-1 Fk506-Binding Protein 1a Fkbp-1a Immunophilin Fkbp12 Rotamase
Database Links	Reactome: R-MMU-166208 Reactome: -MMU-2025928 Reactome: -MMU-2173789
Cellular Localisation	Cytoplasm Cytosol Sarcoplasmic Reticulum Membrane Peripheral Membrane Protein Cytoplasmic Side
Alternative Protein Names	Peptidyl-Prolyl Cis-Trans Isomerase Fkbp1a protein Ppiase Fkbp1a protein 12 Kda Fk506-Binding Protein protein 12 Kda Fkbp protein Fkbp-12 protein Calstabin-1 protein Fk506-Binding Protein 1a protein Fkbp-1a protein Immunophilin Fkbp12 protein Rotamase protein Fkbp1a protein Fkbp1 protein

Information sourced from Uniprot.org