| Host: |
HEK293 cells |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse Fc-gamma RIV/CD16-2-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Gene Symbol: |
Fcgr4 |
| Gene ID: |
246256 |
| Uniprot ID: |
FCG3A_MOUSE |
| Immunogen: |
Recombinant Mouse Fc-gamma RIV/CD16-2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly21-Gln 203) of mouse Fc gamma RIV/CD16-2 (Accession #NP_653142.2) fused with a 6×His tag at the C-terminus. |
| Post Translational Modifications | N-glycosylated. Phosphorylated following receptor ligation. |
| Function | Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Binds with intermediate affinity to both IgG2a and IgG2b. Can bind to IgG2a and IgG2b monomers. Does not display binding to IgG1 or IgG3. Recognizes neutralizing virus-specific IgGs displayed on the cell surface of infected cells and triggers antibody-dependent cellular cytotoxicity (ADCC). Confers protection to lethal influenza virus infection. On splenic dendritic cells, uptakes antigen immune complexes and efficiently divert them into MHC class I and II antigen presentation pathways to provide for superior priming of CD4-positive and CD8-positive T cell immune responses. Mediates neutrophil activation by IgG complexes redundantly with FCGR2A. Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a. Also acts as a receptor for the Fc region of immunoglobulin epsilon (IgE). Binds with low affinity to both the a and b allotypes of IgE. Has also been shown to bind to IgE allotype a only but not to allotype b. Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes. Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of pro-inflammatory cytokines and the late phase of cutaneous allergic reactions. Mediates enhanced ADCC in response to afucosylated IgGs. |
| Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-AIgg Fc Receptor Iii-ACd16-2FcgammarivCd Antigen Cd16a |
| Database Links | Reactome: R-MMU-163125Reactome: -MMU-198933Reactome: -MMU-2029481Reactome: -MMU-2029482Reactome: -MMU-2029485Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-A proteinIgg Fc Receptor Iii-A proteinCd16-2 proteinFcgammariv proteinCd Antigen Cd16a proteinFcgr4 proteinFcgr3a protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
