Mouse Fbxo2 protein (Recombinant) (N-His) (STJP014901)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Mouse Fbxo2-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for this information. |
Target Information
| Gene Symbol | Fbxo2 |
| Gene ID | 230904 |
| Uniprot ID | FBX2_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Phe117-Pro297 |
Additional Info
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type. |
| Protein Name | F-Box Only Protein 2 |
| Database Links | Reactome: R-MMU-8951664Reactome: -MMU-983168 |
| Cellular Localisation | CytoplasmMicrosome MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Protein Names | F-Box Only Protein 2 proteinFbxo2 proteinFbs1 proteinFbx2 protein |
Information sourced from Uniprot.org