Mouse EPO protein (Recombinant) (STJP000374)
SPECIFICATIONS
HostHEK293
ConjugationUnconjugated
ImmunogenDNA sequence encoding the mature chain of Mouse erythropoietin EPO including a C-terminal His tag was expressed in HEK293 Cells. NA
General Information
| Short Description | Recombinant-Mouse EPO-protein was developed from hek293. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers. |
| Formulation | Lyophilised from 0.2 µm filtered PBS solution pH7.4. |
| Storage Instruction | The lyophilized protein is stable for at least 1 year from date of receipt at-20°C. NA |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
| Immunoreactivity | The activity was determined by its ability to bind in functional ELISA assay. NA |
Target Information
| Gene Symbol | Epo |
| Gene ID | 13856 |
| Uniprot ID | EPO_MOUSE |
| Immunogen | DNA sequence encoding the mature chain of Mouse erythropoietin EPO including a C-terminal His tag was expressed in HEK293 Cells. NA |
| Immunogen Region | Mature chain |
| Immunogen Sequence | APPRLICDSR VLERYILEAK EAENVTMGCA EGPRLSENIT VPDTKVNFYA WKRMEVEEQA IEVWQGLSLL SEAILQAQAL LANSSQPPET LQLHIDKAIS GLRSLTSLLR VLGAQKELMS PPDTTPPAPL RTLTVDTFCK LFRVYANFLR GKLKLYTGEV NA |
Additional Info
| Tissue Specificity | Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals. |
| Function | Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. |
| Protein Name | Erythropoietin |
| Database Links | Reactome: R-MMU-9027276Reactome: -MMU-9027284 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Erythropoietin proteinEpo protein |
Information sourced from Uniprot.org