Mouse EpCAM protein (Recombinant) (STJP000677)
SPECIFICATIONS
HostHEK293
ConjugationUnconjugated
ImmunogenOptimized DNA sequence encoding extracellular domain of Mouse Epithelial cell adhesion molecule (EpCAM) (GLN24-THR265) including a C-terminal His tag was expressed in HEK293 cells. NA
General Information
| Short Description | Recombinant-Mouse EpCAM-protein was developed from hek293. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose. |
| Storage Instruction | Can be stored in working aliquots at 2ยฐC-8ยฐC C for one month, or at-20ยฐC to-70ยฐC for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ยตg (1EU/ยตg). NA |
Target Information
| Gene Symbol | Epcam |
| Gene ID | 17075 |
| Uniprot ID | EPCAM_MOUSE |
| Immunogen | Optimized DNA sequence encoding extracellular domain of Mouse Epithelial cell adhesion molecule (EpCAM) (GLN24-THR265) including a C-terminal His tag was expressed in HEK293 cells. NA |
| Immunogen Region | GLN24-THR265 |
Additional Info
| Post Translational Modifications | Glycosylation at Asn-198 is crucial for protein stability. |
| Function | May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. |
| Protein Name | Epithelial Cell Adhesion MoleculeEp-CamEpithelial Glycoprotein 314Egp314Megp314Protein 289aTumor-Associated Calcium Signal Transducer 1Cd Antigen Cd326 |
| Database Links | Reactome: R-MMU-202733 |
| Cellular Localisation | Lateral Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionTight JunctionColocalizes With Cldn7 At The Lateral Cell Membrane And Tight Junction |
| Alternative Protein Names | Epithelial Cell Adhesion Molecule proteinEp-Cam proteinEpithelial Glycoprotein 314 proteinEgp314 proteinMegp314 proteinProtein 289a proteinTumor-Associated Calcium Signal Transducer 1 proteinCd Antigen Cd326 proteinEpcam proteinTacstd1 protein |
Information sourced from Uniprot.org