Mouse CD33 (Siglec-3) protein (Recombinant) (STJP000633)
SPECIFICATIONS
HostHEK293
ConjugationUnconjugated
ImmunogenOptimized DNA sequence encoding extracellular domain of Mouse CD33 including an IgG1 Fc C-terminal His tag was expressed in HEK293 cells. NA
General Information
| Short Description | Recombinant-Mouse CD33 (Siglec-3)-protein was developed from hek293. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose. |
| Storage Instruction | Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
Target Information
| Gene Symbol | Cd33 |
| Gene ID | 12489 |
| Uniprot ID | CD33_MOUSE |
| Immunogen | Optimized DNA sequence encoding extracellular domain of Mouse CD33 including an IgG1 Fc C-terminal His tag was expressed in HEK293 cells. NA |
| Immunogen Region | ECD |
Additional Info
| Tissue Specificity | Expressed on myeloid precursors in the bone marrow. In the peripheral blood, mostly expressed on granulocytes. |
| Post Translational Modifications | Glycosylated. Phosphorylation is involved in binding to PTPN6 and PTPN11. |
| Function | Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially binds sialic acid to the short O-linked glycans of certain mucins. |
| Protein Name | Myeloid Cell Surface Antigen Cd33Sialic Acid-Binding Ig-Like Lectin 3Siglec-3Cd Antigen Cd33 |
| Database Links | Reactome: R-MMU-198933Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Myeloid Cell Surface Antigen Cd33 proteinSialic Acid-Binding Ig-Like Lectin 3 proteinSiglec-3 proteinCd Antigen Cd33 proteinCd33 proteinSiglec3 protein |
Information sourced from Uniprot.org