| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <1 EU/Mu g |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA.Immobilized Mouse CD276 at 2 Mu g/mL (100 Mu L/well) can bind CD276 Rabbit pAb with a linear range of 1-77.4 ng/mL. |
| Gene Symbol: | Cd276 |
| Gene ID: | 102657 |
| Uniprot ID: | CD276_MOUSE |
| Immunogen Region: | Val 29-Phe 244 |
| Immunogen: | Recombinant Mouse CD276 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val 29-Phe 244) of mouse CD276 (Accession #NP_598744.1) fused with and a hFc tag at the C-terminus. |
| Immunogen Sequence: | VEVQVSEDPVVALVDTDATL RCSFSPEPGFSLAQLNLIWQ LTDTKQLVHSFTEGRDQGSA YSNRTALFPDLLVQGNASLR LQRVRVTDEGSYTCFVSIQD FDSAAVSLQVAAPYSKPSMT LEPNKDLRPGNMVTITCSSY QGYPEAEVFWKDGQGVPLTG NVTTSQMANERGLFDVHSVL RVVLGANGTYSCLVRNPVLQ QDAHGSVTITGQPLTF |
| Function | Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. Plays a positive regulatory role in bone formation and has a dual role in the bone-immune interface. Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells. |
| Protein Name | Cd276 Antigen B7 Homolog 3 B7-H3 Costimulatory Molecule Cd Antigen Cd276 |
| Cellular Localisation | Membrane Single-Pass Type I Membrane Protein |
| Alternative Protein Names | Cd276 Antigen protein B7 Homolog 3 protein B7-H3 protein Costimulatory Molecule protein Cd Antigen Cd276 protein Cd276 protein B7h3 protein |
Information sourced from Uniprot.org
