Mouse CCL5/RANTES protein (Recombinant) (N-hFc) (STJP020318)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Mouse CCL5/RANTES Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser24-Ser91) of Mouse CCL5/RANTES (Accession #) fused with hFc tag at the N-terminal.
General Information
| Short Description | Recombinant-Mouse CCL5/RANTES-N-hFc protein was developed in hek293 cells using the region Ser24-Ser91. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | Ccl5 |
| Gene ID | 20304 |
| Uniprot ID | CCL5_MOUSE |
| Immunogen | Recombinant Mouse CCL5/RANTES Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser24-Ser91) of Mouse CCL5/RANTES (Accession #) fused with hFc tag at the N-terminal. |
| Immunogen Region | Ser24-Ser91 |
Additional Info
| Tissue Specificity | T-cell and macrophage specific. |
| Function | Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. |
| Protein Name | C-C Motif Chemokine 5MurantesSis-DeltaSmall-Inducible Cytokine A5T-Cell-Specific Protein Rantes |
| Database Links | Reactome: R-MMU-380108Reactome: -MMU-418594 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 5 proteinMurantes proteinSis-Delta proteinSmall-Inducible Cytokine A5 proteinT-Cell-Specific Protein Rantes proteinCcl5 proteinScya5 protein |
Information sourced from Uniprot.org