Mouse CCL2/MCP-1 protein (Recombinant) (C-His) (STJP002817)

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STJP002817
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: <0.1 EU/Mu g
Immunoreactivity: Measured by its ability to chemoattract THP-1 cells. The ED50 for this effect is typically 6.2-25.0 ng/mL.
Gene Symbol: Ccl2
Gene ID: 20296
Uniprot ID: CCL2_MOUSE
Immunogen Region: Gln 24-Asn148
Immunogen: Recombinant Mouse CCL2/MCP-1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln 24-Asn148) of mouse CCL2/MCP-1 (Accession #NP_035463.1) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: QPDAVNAPLTCCYSFTSKMI PMSRLESYKRITSSRCPKEA VVFVTKLKREVCADPKKEWV QTYIKNLDRNQMRSEPTTLF KTASALRSSAPLNVKLTRKS EANASTTFSTTTSSTSVGVT SVTVN
Function Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B.
Protein Name C-C Motif Chemokine 2
Monocyte Chemoattractant Protein 1
Monocyte Chemotactic Protein 1
Mcp-1
Platelet-Derived Growth Factor-Inducible Protein Je
Small-Inducible Cytokine A2
Cellular Localisation Secreted
Alternative Protein Names C-C Motif Chemokine 2 protein
Monocyte Chemoattractant Protein 1 protein
Monocyte Chemotactic Protein 1 protein
Mcp-1 protein
Platelet-Derived Growth Factor-Inducible Protein Je protein
Small-Inducible Cytokine A2 protein
Ccl2 protein
Je protein
Mcp1 protein
Scya2 protein

Information sourced from Uniprot.org

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