| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from 0.22 Mu m filtered solution in PBS, 250mM NaCl, pH 7.4. Normally 8% Trehalose is added as protectant before lyophilisation. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g |
| Gene Symbol: | Ccl11 |
| Gene ID: | 20292 |
| Uniprot ID: | CCL11_MOUSE |
| Immunogen Region: | His24-Pro97 |
| Immunogen: | Recombinant Mouse CCL11/Eotaxin Protein by Pichia expression system. The target protein is expressed with sequence (His24-Pro97) of Mouse CCL11/Eotaxin (Accession #NP_035460.1) fused with a His tag at the C-terminus.. |
| Immunogen Sequence: | TSHLVKCAEKEKTFCVNGGE CFMVKDLSNPSRYLCKCQPG FTGARCTENVPMKVQNQEKA EELYQKRVLTI |
| Tissue Specificity | Expressed constitutively in the thymus. Expression inducible in the lung (type I alveolar epithelial cells), intestine, heart, spleen, kidney. |
| Function | In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils. Binds to CCR3. |
| Protein Name | EotaxinC-C Motif Chemokine 11Eosinophil Chemotactic ProteinSmall-Inducible Cytokine A11 |
| Database Links | Reactome: R-MMU-380108Reactome: -MMU-418594 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Eotaxin proteinC-C Motif Chemokine 11 proteinEosinophil Chemotactic Protein proteinSmall-Inducible Cytokine A11 proteinCcl11 proteinScya11 protein |
Information sourced from Uniprot.org