Mouse Cathepsin S protein (Recombinant) (STJP000292)
SPECIFICATIONS
HostHEK293
ConjugationUnconjugated
ImmunogenOptimized DNA sequence encoding mature chain of mouse Cathepsin S-CatS (GLN17-ILE331) including a C-terminal His tag was expressed in HEK293 cells. NA
General Information
| Short Description | Recombinant-Mouse Cathepsin S-protein was developed from hek293. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers. |
| Formulation | Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose. |
| Storage Instruction | Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
| Immunoreactivity | The activity was tested by the ability to cleave a flourogenic substrate, the measured activity is 300 pmole/ug/min NA |
Target Information
| Gene Symbol | Ctss |
| Gene ID | 13040 |
| Uniprot ID | CATS_MOUSE |
| Immunogen | Optimized DNA sequence encoding mature chain of mouse Cathepsin S-CatS (GLN17-ILE331) including a C-terminal His tag was expressed in HEK293 cells. NA |
| Immunogen Region | GLN17-ILE331 |
Additional Info
| Tissue Specificity | Widely expressed with highest expression found in non-skeletal tissues. Relatively high levels found in skeletal tissues. Expressed in spleen, B cells, dendritic cells and macrophages. |
| Function | Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L. |
| Protein Name | Cathepsin S |
| Database Links | Reactome: R-MMU-1474228Reactome: -MMU-1679131Reactome: -MMU-2022090Reactome: -MMU-2132295Reactome: -MMU-6798695 |
| Cellular Localisation | LysosomeSecretedCytoplasmic VesiclePhagosome |
| Alternative Protein Names | Cathepsin S proteinCtss proteinCats protein |
Information sourced from Uniprot.org