| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.58ng/mL |
| Detection Limit: | 1.56-100ng/mL |
| Short Description: | This CAPN1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates, cell lysates, cell culture supernates or other biological fluids.. |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | Capn1 |
| Gene ID: | 12333 |
| Uniprot ID: | CAN1_MOUSE |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms. |
| Function | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-388' and 'His-410'. Cleaves and activates caspase-7 (CASP7). |
| Protein Name | Calpain-1 Catalytic Subunit Calcium-Activated Neutral Proteinase 1 Canp 1 Calpain Mu-Type Calpain-1 Large Subunit Micromolar-Calpain Mucanp |
| Database Links | Reactome: R-MMU-1474228 Reactome: -MMU-6798695 |
| Cellular Localisation | Cytoplasm Cell Membrane Translocates To The Plasma Membrane Upon Ca(2+) Binding |
| Alternative ELISA Names | Calpain-1 Catalytic Subunit ELISA kit Calcium-Activated Neutral Proteinase 1 ELISA kit Canp 1 ELISA kit Calpain Mu-Type ELISA kit Calpain-1 Large Subunit ELISA kit Micromolar-Calpain ELISA kit Mucanp ELISA kit Capn1 ELISA kit Canp1 ELISA kit Capa1 ELISA kit |
| output |
Information sourced from Uniprot.org
