This CACNa1C Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates or other biological fluids..
Applications
ELISA
Reactivity
Mouse
Sensitivity
0.115ng/mL
Detection Limit
0.312-20ng/mL
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Storage Instruction
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Detected in embryonic heart. Detected in retina in rod bipolar cells. Detected in tibialis artery (at protein level). Detected in smooth muscle cells from tibialis artery and in mesenteric artery. High expression in heart, followed by brain and spinal cord.
Post Translational Modifications
Phosphorylation by PKA at Ser-1897 activates the channel. Elevated levels of blood glucose lead to increased phosphorylation by PKA.
Function
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).
Protein Name
Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1cCalcium Channel - L Type - Alpha-1 Polypeptide - Isoform 1 - Cardiac MuscleMelc-CcMouse Brain Class CMbcVoltage-Gated Calcium Channel Subunit Alpha Cav1.2
Cell MembraneMulti-Pass Membrane ProteinSarcolemmaPerikaryonPostsynaptic Density MembraneCell ProjectionDendriteT-TubuleColocalizes With Ryanodine Receptors In Distinct Clusters At The Junctional MembraneWhere The Sarcolemma And The Sarcoplasmic Reticulum Are In Close ContactThe Interaction Between Rrad And Cacnb2 Promotes The Expression Of Cacna1c At The Cell MembraneLocalized In T-TubulesAs Shown In Serca2-Knockout Cardiomyocytes
