Mouse C5aR1 (Complement Component 5a Receptor 1) Sandwich ELISA Kit Ready-To-Use Kit (STJE0013981)
SPECIFICATIONS
General Information
| Short Description | This C5aR1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates, cell lysates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Mouse |
| Sensitivity | 0.128ng/mL |
| Detection Limit | 0.312-20ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | C5ar1 |
| Gene ID | 12273 |
| Uniprot ID | C5AR1_MOUSE |
| Immunogen Region | Ready-To-Use |
| Sample Type | tissue homogenates, cell lysates or other biological fluids. |
Additional Info
| Tissue Specificity | |
| Post Translational Modifications | Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist. Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to C5a. |
| Function | Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. |
| Protein Name | C5a Anaphylatoxin Chemotactic Receptor 1C5a Anaphylatoxin Chemotactic ReceptorC5a-RC5arCd Antigen Cd88 |
| Database Links | Reactome: R-MMU-375276Reactome: -MMU-418594Reactome: -MMU-6798695Reactome: -MMU-977606 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmic VesiclePhosphorylated C5ar Colocalizes With Arrb1 And Arrb2 In Cytoplasmic Vesicles |
| Alternative ELISA Names | C5a Anaphylatoxin Chemotactic Receptor 1 ELISA kitC5a Anaphylatoxin Chemotactic Receptor ELISA kitC5a-R ELISA kitC5ar ELISA kitCd Antigen Cd88 ELISA kitC5ar1 ELISA kitC5ar ELISA kitC5r1 ELISA kit |
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Information sourced from Uniprot.org