• Mouse B7-H1/PD-L1/CD274 protein (Recombinant) (C-hFc&His) (STJP001164)
  • Mouse B7-H1/PD-L1/CD274 protein (Recombinant) (C-hFc&His) (STJP001164)
  • Mouse B7-H1/PD-L1/CD274 protein (Recombinant) (C-hFc&His) (STJP001164)
  • Mouse B7-H1/PD-L1/CD274 protein (Recombinant) (C-hFc&His) (STJP001164)

Mouse B7-H1/PD-L1/CD274 protein (Recombinant) (C-hFc&His) (STJP001164)

SKU:
STJP001164

Current Stock:
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse B7-H1/PD-L1/CD274-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse PD-1 at 10 Mu g/mL (100 Mu L/well) can bind Recombinant Mouse PD-L1 with a linear range of 1.5-5 Mu g/mL.
Gene Symbol: Cd274
Gene ID: 60533
Uniprot ID: PD1L1_MOUSE
Immunogen: Recombinant Mouse B7-H1/PD-L1/CD274 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe19-Thr238) of mouse PD-L1/B7-H1 (Accession #NP_068693) fused with an Fc, 6Ă—His tag at the C-terminus.
Post Translational Modifications Ubiquitinated.STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation. Ubiquitinated by MARCHF8.leading to degradation.
Function Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy.
Protein Name Programmed Cell Death 1 Ligand 1
Pd-L1
Pdcd1 Ligand 1
Programmed Death Ligand 1
B7 Homolog 1
B7-H1
Cd Antigen Cd274
Database Links Reactome: R-MMU-389948
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Early Endosome Membrane
Recycling Endosome Membrane
Alternative Protein Names Programmed Cell Death 1 Ligand 1 protein
Pd-L1 protein
Pdcd1 Ligand 1 protein
Programmed Death Ligand 1 protein
B7 Homolog 1 protein
B7-H1 protein
Cd Antigen Cd274 protein
Cd274 protein
B7h1 protein
Pdcd1l1 protein
Pdcd1lg1 protein
Pdl1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance