Mouse ARHGEF7 (Rho Guanine Nucleotide Exchange Factor 7) Sandwich ELISA Kit (STJE0007309)
SPECIFICATIONS
General Information
| Short Description | This ARHGEF7 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Mouse |
| Sensitivity | 34pg/mL |
| Detection Limit | 78.1-5000pg/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | Arhgef7 |
| Gene ID | 54126 |
| Uniprot ID | ARHG7_MOUSE |
| Sample Type | tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | Seems to be expressed in the central nervous system. Isoform B, isoform C and isoform E are expressed with highest levels in brain and testis. |
| Post Translational Modifications | Phosphorylated on Ser-673 by CaMK1.enhancement of GEF activity and downstream activation of RAC1. Phosphorylated by PTK2/FAK1.this promotes interaction with RAC1. |
| Function | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. May function as a positive regulator of apoptosis. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 7Beta-PixPak-Interacting Exchange Factor BetaP85spr |
| Database Links | Reactome: R-MMU-182971Reactome: -MMU-193648Reactome: -MMU-3928664Reactome: -MMU-416482Reactome: -MMU-8980692Reactome: -MMU-9013149Reactome: -MMU-9013406Reactome: -MMU-9013420Reactome: -MMU-9013424 |
| Cellular Localisation | Cell JunctionFocal AdhesionCell ProjectionRuffleCytoplasmCell CortexLamellipodiumDetected At Cell AdhesionsA Small Proportion Is Detected At Focal Adhesions |
| Alternative ELISA Names | Rho Guanine Nucleotide Exchange Factor 7 ELISA kitBeta-Pix ELISA kitPak-Interacting Exchange Factor Beta ELISA kitP85spr ELISA kitArhgef7 ELISA kitKiaa0142 ELISA kitPak3bp ELISA kit |
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Information sourced from Uniprot.org