Mouse Angiopoietin 2/ANG2 (Angiopoietin 2/ANG2) Antibody Pair (STJAP00758)
General Information
| Short Description | This Angiopoietin 2/ANG2 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R46-4B-1/R13-1P-8 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | Angpt2 |
| Gene ID | 11601 |
| Uniprot ID | ANGP2_MOUSE |
| Immunogen | Recombinant protein |
Additional Info
| Tissue Specificity | Expressed in the ovary, uterus and placenta. |
| Function | Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis. |
| Protein Name | Angiopoietin-2Ang-2 |
| Database Links | Reactome: R-MMU-210993 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Angiopoietin-2 antibody pairAng-2 antibody pairAngpt2 antibody pairAgpt2 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Mouse Angiopoietin 2/ANG2 (Angiopoietin 2/ANG2) Antibody Pair (STJAP00758)
This antibody pair detects mouse Angiopoietin 2 (ANG2), corresponding to UniProt accession O35608. Reactivity has been confirmed for mouse only.
Both antibodies are rabbit monoclonal IgGs supplied unconjugated at 1 mg/mL in 0.01M PBS, pH 7.2. Both have been affinity purified, with clone IDs R46-4B-1 and R13-1P-8 respectively.
This antibody pair is validated for use in ELISA. No other assay formats are listed in the product specifications.
Working concentrations are determined by the end user and are not predefined in the product specifications. Titration experiments are recommended to establish optimal concentrations for each specific assay setup.
Both antibodies should be stored at 4°C for short-term use. For long-term storage, aliquot and store at -20°C, and avoid repeated freeze/thaw cycles.
Both antibodies were raised in rabbit against a recombinant mouse Angiopoietin 2 protein. No further details regarding the specific immunogen region are provided in the product specifications.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.