SDS-PAGE gel of recombinant mouse alpha-Synuclein protein under reducing conditions

Mouse alpha-Synuclein protein (Recombinant) (No-Tag) (STJP016759)

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STJP016759
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Short Description :Recombinant-Mouse alpha-Synuclein-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 7.5) containing, 10% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:Snca
Gene ID:20617
Uniprot ID:SYUA_MOUSE
Accession Number:NP_033247
Immunogen:Mouse
Immunogen Region:1-140aa
Immunogen Sequence:MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM GKGEEGYPQE GILEDMPVDP GSEAYEMPSE EGYQDYEPEA
Tissue Specificity Expressed in brain (at protein level). Expressed in the striatum (at protein level). Highly expressed in presynaptic terminals in the central nervous system.
Post Translational Modifications Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress. Ubiquitinated. The predominant conjugate is the diubiquitinated form. Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.
Function Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
Protein Name Alpha-Synuclein
Non-A Beta Component Of Ad Amyloid
Non-A4 Component Of Amyloid Precursor
Nacp
Database Links Reactome: R-MMU-9833482
Cellular Localisation Cytoplasm
Membrane
Nucleus
Synapse
Secreted
Cell Projection
Axon
Membrane-Bound In Dopaminergic Neurons
Expressed And Colocalized With Septin4 In Dopaminergic Axon Terminals
Especially At The Varicosities
Alternative Protein Names Alpha-Synuclein protein
Non-A Beta Component Of Ad Amyloid protein
Non-A4 Component Of Amyloid Precursor protein
Nacp protein
Snca protein
Syn protein

Information sourced from Uniprot.org

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