MeCP2 isoform 1 Positive Control for STJ501740 peptide (STJ505350)

SKU:
STJ505350-5

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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: MeCP2 isoform 1 Positive Control for STJ501740 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: MECP2
Gene ID: 4204
Uniprot ID: MECP2_HUMAN
Specificity: This is positive control is recommended for use in combination with MeCP2 isoform 1 antibody STJ501740.
Immunogen: Purified Protein
Tissue Specificity Present in all adult somatic tissues tested.
Post Translational Modifications Phosphorylated on Ser-423 in brain upon synaptic activity, which attenuates its repressor activity and seems to regulate dendritic growth and spine maturation.
Function Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Peptide Name Methyl-Cpg-Binding Protein 2
Mecp-2 Protein
Mecp2
Database Links Reactome: R-HSA-8986944
Reactome: R-HSA-9022534
Reactome: R-HSA-9022535
Reactome: R-HSA-9022537
Reactome: R-HSA-9022538
Reactome: R-HSA-9022692
Reactome: R-HSA-9022699
Reactome: R-HSA-9022702
Reactome: R-HSA-9022707
Reactome: R-HSA-9022927
Reactome: R-HSA-9725371
Cellular Localisation Nucleus
Colocalized With Methyl-Cpg In The Genome
Colocalized With Tbl1x To The Heterochromatin Foci
Alternative Peptide Names Methyl-Cpg-Binding Protein 2 protein
Mecp-2 Protein protein
Mecp2 protein
MECP2 protein

Information sourced from Uniprot.org

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