| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
MASH1/Achaete-scute homolog 1 Positive Control for STJ506350 is synthetically produced from the 1175-225 sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
ASCL1 |
| Gene ID: |
429 |
| Uniprot ID: |
ASCL1_HUMAN |
| Immunogen Region: |
1175-225 |
| Specificity: |
This is positive control is recommended for use in combination with MASH1/Achaete-scute homolog 1 antibody STJ506350. |
| Immunogen: |
Partially purified human Achaete-scute homolog 1 protein. |
| Function | Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Involved in the regulation of neuroendocrine cell development in the glandular stomach. |
| Peptide Name | Achaete-Scute Homolog 1Ash-1Hash1Class A Basic Helix-Loop-Helix Protein 46Bhlha46 |
| Database Links | Reactome: R-HSA-9031628 |
| Cellular Localisation | Nucleus |
| Alternative Peptide Names | Achaete-Scute Homolog 1 proteinAsh-1 proteinHash1 proteinClass A Basic Helix-Loop-Helix Protein 46 proteinBhlha46 proteinASCL1 proteinASH1 proteinBHLHA46 proteinHASH1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
