MAPK6 Blocking Peptide for STJ501708 peptide (STJ505446)
SPECIFICATIONS
ImmunogenSynthetic peptide taken within amino acid region 480-530 on human Mitogen-activated protein kinase 6.
General Information
| Short Description | MAPK6 Blocking Peptide for STJ501708 is synthetically produced from the 480-530 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | MAPK6 |
| Gene ID | 5597 |
| Uniprot ID | MK06_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 480-530 on human Mitogen-activated protein kinase 6. |
| Immunogen Region | 480-530 |
| Specificity | This blocking peptide is recommended for use in combination with MAPK6 antibody, STJ501708 |
Additional Info
| Tissue Specificity | Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts. |
| Post Translational Modifications | Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites. Ubiquitination at Met-1 leads to degradation by the proteasome pathway. |
| Function | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle. |
| Peptide Name | Mitogen-Activated Protein Kinase 6Map Kinase 6Mapk 6Extracellular Signal-Regulated Kinase 3Erk-3Map Kinase Isoform P97P97-Mapk |
| Database Links | Reactome: R-HSA-5687128 |
| Cellular Localisation | CytoplasmNucleusTranslocates To The Cytoplasm Following Interaction With Mapkapk5 |
| Alternative Peptide Names | Mitogen-Activated Protein Kinase 6 proteinMap Kinase 6 proteinMapk 6 proteinExtracellular Signal-Regulated Kinase 3 proteinErk-3 proteinMap Kinase Isoform P97 proteinP97-Mapk proteinMAPK6 proteinERK3 proteinPRKM6 protein |
Information sourced from Uniprot.org