MAP3K12 Blocking Peptide peptide (Phospho) (STJ504749)

SKU:
STJ504749-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Phospho-MAP3K12 Blocking Peptide is synthetically produced from the 270-320 sequence and is suitable for use in western blot applications.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: MAP3K12
Gene ID: 7786
Uniprot ID: M3K12_HUMAN
Immunogen Region: 270-320
Immunogen: Synthetic peptide taken within amino acid region 270-320 on MAP3K12 protein. Phosphorylated S298 & S302 residues.
Tissue Specificity Highly expressed in brain and kidney.
Post Translational Modifications Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated. The activity of MAP3K12 can be regulated through its proteasomal degradation. APOE, through a receptor-mediated mechanism, activates MAP3K12 by preventing its proteasomal degradation.
Function Part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway.
Peptide Name Mitogen-Activated Protein Kinase Kinase Kinase 12
Dual Leucine Zipper Bearing Kinase
Dlk
Leucine-Zipper Protein Kinase
Zpk
Mapk-Upstream Kinase
Muk
Mixed Lineage Kinase
Cellular Localisation Cytoplasm
Cell Membrane
Behaves Essentially As An Integral Membrane Protein
Alternative Peptide Names Mitogen-Activated Protein Kinase Kinase Kinase 12 protein
Dual Leucine Zipper Bearing Kinase protein
Dlk protein
Leucine-Zipper Protein Kinase protein
Zpk protein
Mapk-Upstream Kinase protein
Muk protein
Mixed Lineage Kinase protein
MAP3K12 protein
ZPK protein

Information sourced from Uniprot.org

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