LRRK1 Positive Control for STJ501638 peptide (STJ505625)
SPECIFICATIONS
ImmunogenPurfied protein.
General Information
| Short Description | LRRK1 Positive Control for STJ501638 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | WB |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | WB: 1:2, 500-1:5, 000 |
| Formulation | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | LRRK1 |
| Gene ID | 79705 |
| Uniprot ID | LRRK1_HUMAN |
| Immunogen | Purfied protein. |
| Specificity | This is positive control is recommended for use in combination with LRRK1 antibody STJ501638. |
Additional Info
| Post Translational Modifications | Autophosphorylated. Autophosphorylation is inhibited in its dimeric state. Phosphorylated by protein kinase C isozymes PRKCA, PRKCB, PRKCG, PRKCE, PRKCZ and PRKCT at Thr-1061, Ser-1064, Ser-1074 and Thr-1075. Phosphorylation at these Ser-1064, Ser-1074 and Thr-1075 activates the kinase activity of LRRK1 to phosphorylate RAB7A. |
| Function | Serine/threonine-protein kinase which phosphorylates RAB proteins involved in intracellular trafficking. Phosphorylates RAB7A.this activity is dependent on protein kinase C (PKC) activation. Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts. |
| Peptide Name | Leucine-Rich Repeat Serine/Threonine-Protein Kinase 1 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane Protein |
| Alternative Peptide Names | Leucine-Rich Repeat Serine/Threonine-Protein Kinase 1 proteinLRRK1 proteinKIAA1790 protein |
Information sourced from Uniprot.org