LRRK1 Blocking Peptide for STJ501636 peptide (STJ505624)
SPECIFICATIONS
ImmunogenSynthetic peptide taken within amino acid region 1950-2015 on human Leucine-rich repeat serine/threonine-protein kinase 1 protein.
General Information
| Short Description | LRRK1 Blocking Peptide for STJ501636 is synthetically produced from the 1950-2015 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | LRRK1 |
| Gene ID | 79705 |
| Uniprot ID | LRRK1_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 1950-2015 on human Leucine-rich repeat serine/threonine-protein kinase 1 protein. |
| Immunogen Region | 1950-2015 |
| Specificity | This blocking peptide is recommended for use in combination with LRRK1 antibody, STJ501636 |
Additional Info
| Post Translational Modifications | Autophosphorylated. Autophosphorylation is inhibited in its dimeric state. Phosphorylated by protein kinase C isozymes PRKCA, PRKCB, PRKCG, PRKCE, PRKCZ and PRKCT at Thr-1061, Ser-1064, Ser-1074 and Thr-1075. Phosphorylation at these Ser-1064, Ser-1074 and Thr-1075 activates the kinase activity of LRRK1 to phosphorylate RAB7A. |
| Function | Serine/threonine-protein kinase which phosphorylates RAB proteins involved in intracellular trafficking. Phosphorylates RAB7A.this activity is dependent on protein kinase C (PKC) activation. Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts. |
| Peptide Name | Leucine-Rich Repeat Serine/Threonine-Protein Kinase 1 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane Protein |
| Alternative Peptide Names | Leucine-Rich Repeat Serine/Threonine-Protein Kinase 1 proteinLRRK1 proteinKIAA1790 protein |
Information sourced from Uniprot.org