Junctional Adhesion Molecule 1 Blocking Peptide peptide (STJ504274)
SPECIFICATIONS
ImmunogenSynthetic peptide corresponding to human JamaA protein.
General Information
| Short Description | Junctional Adhesion Molecule 1 Blocking Peptide is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | F11R |
| Gene ID | 50848 |
| Uniprot ID | JAM1_HUMAN |
| Immunogen | Synthetic peptide corresponding to human JamaA protein. |
Additional Info
| Tissue Specificity | Expressed in endothelium, epithelium and leukocytes (at protein level). |
| Post Translational Modifications | N-glycosylated. (Microbial infection) Cleaved by H.pylori virulence factor PqqE. Cleavage leads to altered tight junction functions. |
| Function | Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. |
| Peptide Name | Junctional Adhesion Molecule AJam-AJunctional Adhesion Molecule 1Jam-1Platelet F11 ReceptorPlatelet Adhesion Molecule 1Pam-1Cd Antigen Cd321 |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-216083Reactome: R-HSA-2173791Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneSingle-Pass Type I Membrane ProteinLocalized At Tight Junctions Of Both Epithelial And Endothelial Cells |
| Alternative Peptide Names | Junctional Adhesion Molecule A proteinJam-A proteinJunctional Adhesion Molecule 1 proteinJam-1 proteinPlatelet F11 Receptor proteinPlatelet Adhesion Molecule 1 proteinPam-1 proteinCd Antigen Cd321 proteinF11R proteinJAM1 proteinJCAM proteinUNQ264 proteinPRO301 protein |
Information sourced from Uniprot.org